Haseeba Shahzad1*, Saba Saeed2, Hajira Kalsoom1, Fizza Mubashir1, Zulqurnain Khan3*, Khunsa Tariq4, Iqra Azhar5, Ayesha Liaqat6, Faiza Farooq7, Huma Butt8
1School of Biochemistry and Biotechnology, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
2Institute of Biochemistry and Biotechnology, The University of Veterinary and Animal Sciences, Lahore, Pakistan
3Institute of Plant Breeding and Biotechnology (IPBB), MNS University of Agriculture, Multan 66000, Pakistan
4Institute of Biochemistry and Molecular Biology, Heinrich Heine University Düsseldorf, Germany
5Department of Biochemistry, Faculty of Biological sciences Quaid-i-Azam University, Islamabad 45320, Pakistan
6School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
7College of Pharmacy, University of Manitoba, Canada
8Department of Pharmaceutics, The Islamia University of Bahawalpur, Pakistan
*For Correspondence
haseebashahzad388@gmail.com
zulqurnain.khan@mnsuam.edu.pk
Publication Date: October 19, 2023Messenger
RNA (mRNA) is in the spotlight as a striking tool for the intervention of
various human disorders chiefly malignant tumors, now a days. Thanks to the
excellent clinical consequences of mRNA vaccines. Recent propitious preclinical
and clinical outcomes that typify the headway in mRNA and nanoformulation-based
delivery scaffolds have illuminated the efficacious aptitude of mRNA in cancer
immunotherapy. The mRNA can be used for cancer immunotherapy in the form of
many therapeutic techniques like adoptive T-cell therapy, therapeutic
antibodies, cancer vaccines and immunomodulatory proteins. This chapter
highlights the comprehensive overview of the evolving role of mRNA technology
against cancer, the underlying mode of action of various types of emerging
mRNA-based cancer vaccines as well as immunomodulatory proteins, current status
and anticipation of mRNA-based therapeutics inclusive of various delivery
strategies as well as has opened new avenues to overcome the deficiencies.
Keywords
mRNA Technology, Cancer Immuno-therapy, Biochemical, Clinical Aspects, Recent Study
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